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維蘭特羅三苯乙酸鹽

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Vilanterol Trifenatate (Synonyms: Vilanterol Trifenate; GW642444 trifenatate)

產(chǎn)品編號(hào):CL1181 CAS No.:503070-58-4 MDLNo: 分子式:C44H49Cl2NO7 分子量:774.77
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基本信息
英文名稱(chēng) Vilanterol Trifenatate (Synonyms: Vilanterol Trifenate; GW642444 trifenatate)
中文名稱(chēng)維蘭特羅三苯乙酸鹽
CAS號(hào)503070-58-4
分子式C44H49Cl2NO7
分子量774.77
外觀(guān)White to off-white powder
儲(chǔ)存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

 Vilanterol, also known as GW-642444, is a long-acting beta-2 agonist. It selectively induces cAMP accumulation in CHO cells expressing the β2-AR over the β1- and β3-ARs (EC50s = 0.4, 398, and 794 nM for the human receptors, respectively). Vilanterol inhibits contractions induced by electrical stimulation in isolated superfused guinea pig trachea strips. It inhibits bronchospasms induced by histamine. Formulations containing vilanterol, in combination with fluticasone, have been used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma.

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